T-cell alloimmunity and chronic allograft dysfunction
نویسندگان
چکیده
منابع مشابه
Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...
متن کاملregulatory t cell subtypes and tgf-β1 gene expression in chronic allograft dysfunction
background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...
متن کاملChronic renal allograft dysfunction.
The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...
متن کاملChronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition.
Chronic graft dysfunction is now the leading clinical problem after renal transplantation. The principal histopathologic lesion seen in this disease is tubular loss with concurrent interstitial fibrosis. Although the severity of acute rejection often correlates with that of subsequent chronic dysfunction, a direct link between these processes has remained elusive. This study was designed to tes...
متن کاملRegulatory T cell subtypes and TGF-β1 gene expression in chronic allograft dysfunction.
BACKGROUND Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF-β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. OBJECTIVES To eval...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2010
ISSN: 0085-2538
DOI: 10.1038/ki.2010.416